![]() ![]() Chimeras are routinely used in diagnostic tests, for example to test sperm fertility.Chimeric mice with human neurons may identify treatments for devastating neural diseases, such as Alzheimer’s and Huntington’s diseases.Mouse-human chimeras enable modeling stem cell replacement therapies to treat diseases such as diabetes or Parkinson’s.Human-mouse chimeras reveal how certain organs are diseased and how the resulting disease can be treated, for example studying human hepatitis virus infection and human-liver specific drug response in mice with human livers.Mice engineered to have immune systems similar to humans allow scientists to study human immunity and autoimmune diseases and test new treatments for infectious diseases, including human-specific infectious diseases.Human cancer cells transferred into specialized mice help scientists explain how cancers spread and uncover new anti-cancer therapies.Human-animal chimeras have been used for decades to better approximate how the human body works and identify new treatments for various diseases, examples include: While non-chimeric animals have been used to successfully model many human diseases, they cannot always replicate the human condition. How is Research Involving Chimeras Applied to Improve Human Health? Chimeric embryos help scientists understand disease progression, identify new therapies, and may be a potential source of organs for transplantation in the future. These chimeras went on to help inform our understanding of brain development, epilepsy, and other disorders. In the 1960s, scientists conducted pioneering work transplanting quail cells into a developing chick embryo, which provided groundbreaking insight into how cells contribute to specific systems, tissues, and structures. Chimerism can occur in nature (for example a mother’s cells can be found in her child decades later, just as a child’s cells can remain in their mother), can be the result of a transplant (such as a bone marrow or organ transplantation from a human donor or tissue transplantation from an animal donor, such as a pig heart valve), or chimeric animals can be created in the lab as part of biomedical research.Ĭhimeras have been studied by scientists for decades. Chimeras are persons or animals that have some living cells in their body that came from another person or animal.
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